Ontology highlight
ABSTRACT:
SUBMITTER: Nemlich Y
PROVIDER: S-EPMC3668823 | biostudies-other | 2013 Jun
REPOSITORIES: biostudies-other
Nemlich Yael Y Greenberg Eyal E Ortenberg Rona R Besser Michal J MJ Barshack Iris I Jacob-Hirsch Jasmine J Jacoby Elad E Eyal Eran E Rivkin Ludmila L Prieto Victor G VG Chakravarti Nitin N Duncan Lyn M LM Kallenberg David M DM Galun Eitan E Bennett Dorothy C DC Amariglio Ninette N Bar-Eli Menashe M Schachter Jacob J Rechavi Gideon G Markel Gal G
The Journal of clinical investigation 20130601 6
Some solid tumors have reduced posttranscriptional RNA editing by adenosine deaminase acting on RNA (ADAR) enzymes, but the functional significance of this alteration has been unclear. Here, we found the primary RNA-editing enzyme ADAR1 is frequently reduced in metastatic melanomas. In situ analysis of melanoma samples using progression tissue microarrays indicated a substantial downregulation of ADAR1 during the metastatic transition. Further, ADAR1 knockdown altered cell morphology, promoted i ...[more]