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Selective Binding of Dopamine and Epinephrine in Water by Molecularly Imprinted Fluorescent Receptors.

ABSTRACT: Catecholamines play important roles in biology but their structural similarity makes it challenging to construct synthetic receptors with selective binding. A combination of covalent and noncovalent binding groups in the hydrophobic core of water-soluble nanoparticles enabled them to recognize dopamine and epinephrine with an association constant (Ka ) of 3-4×104 M-1 in water, an order of magnitude higher than those of previously reported synthetic hosts. In addition, minute structural changes among analogues were detected including the addition or removal of a single hydroxyl or methyl group.

SUBMITTER: Duan L

PROVIDER: S-EPMC7480134 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Water-Soluble Molecularly Imprinted Nanoparticle Receptors with Hydrogen-Bond-Assisted Hydrophobic Binding.

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