Selective Binding of Dopamine and Epinephrine in Water by Molecularly Imprinted Fluorescent Receptors.
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ABSTRACT: Catecholamines play important roles in biology but their structural similarity makes it challenging to construct synthetic receptors with selective binding. A combination of covalent and noncovalent binding groups in the hydrophobic core of water-soluble nanoparticles enabled them to recognize dopamine and epinephrine with an association constant (Ka ) of 3-4×104 M-1 in water, an order of magnitude higher than those of previously reported synthetic hosts. In addition, minute structural changes among analogues were detected including the addition or removal of a single hydroxyl or methyl group.
SUBMITTER: Duan L
PROVIDER: S-EPMC7480134 | biostudies-literature |
REPOSITORIES: biostudies-literature
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