Ontology highlight
ABSTRACT:
SUBMITTER: Duan L
PROVIDER: S-EPMC7480134 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Chemistry, an Asian journal 20200309 7
Catecholamines play important roles in biology but their structural similarity makes it challenging to construct synthetic receptors with selective binding. A combination of covalent and noncovalent binding groups in the hydrophobic core of water-soluble nanoparticles enabled them to recognize dopamine and epinephrine with an association constant (K<sub>a</sub> ) of 3-4×10<sup>4</sup> M<sup>-1</sup> in water, an order of magnitude higher than those of previously reported synthetic hosts. In add ...[more]