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Selective Binding of Dopamine and Epinephrine in Water by Molecularly Imprinted Fluorescent Receptors.


ABSTRACT: Catecholamines play important roles in biology but their structural similarity makes it challenging to construct synthetic receptors with selective binding. A combination of covalent and noncovalent binding groups in the hydrophobic core of water-soluble nanoparticles enabled them to recognize dopamine and epinephrine with an association constant (Ka ) of 3-4×104  M-1 in water, an order of magnitude higher than those of previously reported synthetic hosts. In addition, minute structural changes among analogues were detected including the addition or removal of a single hydroxyl or methyl group.

SUBMITTER: Duan L 

PROVIDER: S-EPMC7480134 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Selective Binding of Dopamine and Epinephrine in Water by Molecularly Imprinted Fluorescent Receptors.

Duan Likun L   Zhao Yan Y  

Chemistry, an Asian journal 20200309 7


Catecholamines play important roles in biology but their structural similarity makes it challenging to construct synthetic receptors with selective binding. A combination of covalent and noncovalent binding groups in the hydrophobic core of water-soluble nanoparticles enabled them to recognize dopamine and epinephrine with an association constant (K<sub>a</sub> ) of 3-4×10<sup>4</sup>  M<sup>-1</sup> in water, an order of magnitude higher than those of previously reported synthetic hosts. In add  ...[more]

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