Ontology highlight
ABSTRACT:
SUBMITTER: Appelberg S
PROVIDER: S-EPMC7473213 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Appelberg Sofia S Gupta Soham S Svensson Akusjärvi Sara S Ambikan Anoop T AT Mikaeloff Flora F Saccon Elisa E Végvári Ákos Á Benfeitas Rui R Sperk Maike M Ståhlberg Marie M Krishnan Shuba S Singh Kamal K Penninger Josef M JM Mirazimi Ali A Neogi Ujjwal U
Emerging microbes & infections 20201201 1
How severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections engage cellular host pathways and innate immunity in infected cells remains largely elusive. We performed an integrative proteo-transcriptomics analysis in SARS-CoV-2 infected Huh7 cells to map the cellular response to the invading virus over time. We identified four pathways, ErbB, HIF-1, mTOR and TNF signaling, among others that were markedly modulated during the course of the SARS-CoV-2 infection <i>in vitro</i>. West ...[more]