Ontology highlight
ABSTRACT:
SUBMITTER: Chen D
PROVIDER: S-EPMC7473300 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Chen Danni D Bao Chang C Zhao Feng F Yu Haogang H Zhong Guansheng G Xu Liang L Yan Senxiang S
Frontiers in oncology 20200821
Breast cancer is the most prevalent type of malignancy in women worldwide. Taxanes (paclitaxel and docetaxel) are widely applied as first-line chemotherapeutic agents, while the therapeutic effect is seriously limited by the development of drug resistance. In the present study, we screened out several miRNAs dysregulated in taxanes-resistant breast cancer samples and confirmed that two miRNAs (miR-335-5p and let-7c-5p) played a major role in cell proliferation, apoptosis, and chemo-resistance. I ...[more]