Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC7474109 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Zhang Yuxin Y An Lufan L Zhang Lin L Wang Rulin R Tian Yuan Y Zhang Zunjian Z
Journal of pharmaceutical analysis 20200303 4
Nafamostat mesylate is a serine protease inhibitor used in the treatment of acute pancreatitis. The impurities in nafamostat mesylate, the active pharmaceutical ingredient (API), were profiled via high performance liquid chromatography tandem ion trap coupled with time-of-flight mass spectrometer (HPLC-IT-TOF/MS). The chromatography was performed on an ACE-3 C<sub>18</sub> column (200 mm × 4.6 mm, 3 μm) using methanol and 0.1% formic acid in purified water as mobile phase at a flow rate of 1.0 m ...[more]