Ontology highlight
ABSTRACT:
SUBMITTER: Britton GJ
PROVIDER: S-EPMC7474624 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Britton Graham J GJ Contijoch Eduardo J EJ Spindler Matthew P MP Aggarwala Varun V Dogan Belgin B Bongers Gerold G San Mateo Lani L Baltus Andrew A Das Anuk A Gevers Dirk D Borody Thomas J TJ Kaakoush Nadeem O NO Kamm Michael A MA Mitchell Hazel H Paramsothy Sudarshan S Clemente Jose C JC Colombel Jean-Frederic JF Simpson Kenneth W KW Dubinsky Marla C MC Grinspan Ari A Faith Jeremiah J JJ
Proceedings of the National Academy of Sciences of the United States of America 20200818 35
The building evidence for the contribution of microbiota to human disease has spurred an effort to develop therapies that target the gut microbiota. This is particularly evident in inflammatory bowel diseases (IBDs), where clinical trials of fecal microbiota transplantation have shown some efficacy. To aid the development of novel microbiota-targeted therapies and to better understand the biology underpinning such treatments, we have used gnotobiotic mice to model microbiota manipulations in the ...[more]