Ontology highlight
ABSTRACT:
SUBMITTER: Tapia-Rojo R
PROVIDER: S-EPMC7474635 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Tapia-Rojo Rafael R Alonso-Caballero Álvaro Á Fernández Julio M JM
Proceedings of the National Academy of Sciences of the United States of America 20200817 35
Cells continually sample their mechanical environment using exquisite force sensors such as talin, whose folding status triggers mechanotransduction pathways by recruiting binding partners. Mechanical signals in biology change quickly over time and are often embedded in noise; however, the mechanics of force-sensing proteins have only been tested using simple force protocols, such as constant or ramped forces. Here, using our magnetic tape head tweezers design, we measure the folding dynamics of ...[more]