Ontology highlight
ABSTRACT:
SUBMITTER: Johansson V
PROVIDER: S-EPMC7474706 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
European archives of psychiatry and clinical neuroscience 20190713 7
Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. We here perform a secondary analysis of kynurenine metabolites and MCP-1 in cerebrospinal fluid of 23 twins affected from schizophrenia, bipolar disorder or unaffected. We show an association between MCP-1 and kynurenic acid (KYNA), driven by unique environmental influences and a less pronounced association between MCP- ...[more]