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Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid.


ABSTRACT: Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. We here perform a secondary analysis of kynurenine metabolites and MCP-1 in cerebrospinal fluid of 23 twins affected from schizophrenia, bipolar disorder or unaffected. We show an association between MCP-1 and kynurenic acid (KYNA), driven by unique environmental influences and a less pronounced association between MCP-1 and tryptophan. No association was detected between MCP-1 and quinolinic acid. Further studies on the mechanism behind the putative relationship between KYNA and MCP-1 are needed.

SUBMITTER: Johansson V 

PROVIDER: S-EPMC7474706 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Twin study shows association between monocyte chemoattractant protein-1 and kynurenic acid in cerebrospinal fluid.

Johansson Viktoria V   Erhardt Sophie S   Engberg Göran G   Kegel Magdalena M   Bhat Maria M   Schwieler Lilly L   Blennow Kaj K   Zetterberg Henrik H   Cannon Tyrone D TD   Wetterberg Lennart L   Hultman Christina M CM   Landén Mikael M  

European archives of psychiatry and clinical neuroscience 20190713 7


Preclinical studies indicate a link between the kynurenine pathway and monocyte chemoattractant protein-1 (MCP-1), but there is a lack of clinical studies examining this further. We here perform a secondary analysis of kynurenine metabolites and MCP-1 in cerebrospinal fluid of 23 twins affected from schizophrenia, bipolar disorder or unaffected. We show an association between MCP-1 and kynurenic acid (KYNA), driven by unique environmental influences and a less pronounced association between MCP-  ...[more]

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