Ontology highlight
ABSTRACT:
SUBMITTER: Anderson JR
PROVIDER: S-EPMC7476031 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Anderson James R JR Phelan Marie M MM Foddy Laura L Clegg Peter D PD Peffers Mandy J MJ
Journal of proteome research 20200806 9
Osteoarthritis is an age-related degenerative musculoskeletal disease characterized by loss of articular cartilage, synovitis, and subchondral bone sclerosis. Osteoarthritis pathogenesis is yet to be fully elucidated with no osteoarthritis-specific biomarkers in clinical use. <i>Ex vivo</i> equine cartilage explants (<i>n</i> = 5) were incubated in tumor necrosis factor-α (TNF-α)/interleukin-1β (IL-1β)-supplemented culture media for 8 days, with the media removed and replaced at 2, 5, and 8 days ...[more]