Dataset Information

Ghrelin ameliorates tumor-induced adipose tissue atrophy and inflammation via Ghrelin receptor-dependent and -independent pathways.

ABSTRACT: Adipose tissue (AT) atrophy is a hallmark of cancer cachexia contributing to increased morbidity/mortality. Ghrelin has been proposed as a treatment for cancer cachexia partly by preventing AT atrophy. However, the mechanisms mediating ghrelin's effects are incompletely understood, including the extent to which its only known receptor, GHSR-1a, is required for these effects. This study characterizes the pathways involved in AT atrophy in the Lewis Lung Carcinoma (LLC)-induced cachexia model and those mediating the effects of ghrelin in Ghsr +/+ and Ghsr -/- mice. We show that LLC causes AT atrophy by inducing anorexia, and increasing lipolysis, AT inflammation, thermogenesis and energy expenditure. These changes were greater in Ghsr -/-. Ghrelin administration prevented LLC-induced anorexia only in Ghsr +/+, but prevented WAT lipolysis, inflammation and atrophy in both genotypes, although its effects were greater in Ghsr +/+. LLC-induced increases in BAT inflammation, WAT and BAT thermogenesis, and energy expenditure were not affected by ghrelin. In conclusion, ghrelin ameliorates WAT inflammation, fat atrophy and anorexia in LLC-induced cachexia. GHSR-1a is required for ghrelin's orexigenic effect but not for its anti-inflammatory or fat-sparing effects.

SUBMITTER: Liu H

PROVIDER: S-EPMC7476735 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Ghrelin ameliorates tumor-induced adipose tissue atrophy and inflammation <i>via</i> Ghrelin receptor-dependent and -independent pathways.

Liu Haiming H Luo Jiaohua J Guillory Bobby B Chen Ji-An JA Zang Pu P Yoeli Jordan K JK Hernandez Yamileth Y Lee Ian In-Gi II Anderson Barbara B Storie Mackenzie M Tewnion Alison A Garcia Jose M JM

Oncotarget 20200901 35

Adipose tissue (AT) atrophy is a hallmark of cancer cachexia contributing to increased morbidity/mortality. Ghrelin has been proposed as a treatment for cancer cachexia partly by preventing AT atrophy. However, the mechanisms mediating ghrelin's effects are incompletely understood, including the extent to which its only known receptor, GHSR-1a, is required for these effects. This study characterizes the pathways involved in AT atrophy in the Lewis Lung Carcinoma (LLC)-induced cachexia model and ...[more]

PMID: 32934774

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Dataset Information

Ghrelin ameliorates tumor-induced adipose tissue atrophy and inflammation via Ghrelin receptor-dependent and -independent pathways.

Publications

Ghrelin ameliorates tumor-induced adipose tissue atrophy and inflammation <i>via</i> Ghrelin receptor-dependent and -independent pathways.

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