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Dataset on Insilico approaches for 3,4-dihydropyrimidin-2(1H)-one urea derivatives as efficient Staphylococcus aureus inhibitor.


ABSTRACT: Series of anti- Staphylococcus aureus were studied via quantum chemical method and several molecular descriptors were obtained which were further used to develop QSAR model using back propagation neural network method using MATLAB. More so, the molecular interaction observed between 3,4-dihydropyrimidin-2(1H)-one Urea Derivatives and Staphylococcus aureus Sortase (PDB ID Code: 2kid) via docking was used as a screening tool for the studied compounds. The observed molecular compounds used in this work was also correlated to Lipinski rule of five and the developed QSAR model using selected descriptors from the optimized compounds was also examined for its predictability. Also, the observed molecular docking revealed the interaction between the studied complex.

SUBMITTER: Oyebamiji AK 

PROVIDER: S-EPMC7476855 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Dataset on <i>Insilico</i> approaches for 3,4-dihydropyrimidin-2(1H)-one urea derivatives as efficient Staphylococcus aureus inhibitor.

Oyebamiji Abel Kolawole AK   Abdulsalami Ibrahim O IO   Semire Banjo B  

Data in brief 20200819


Series of anti- Staphylococcus aureus were studied via quantum chemical method and several molecular descriptors were obtained which were further used to develop QSAR model using back propagation neural network method using MATLAB. More so, the molecular interaction observed between 3,4-dihydropyrimidin-2(1H)-one Urea Derivatives and <i>Staphylococcus aureus</i> Sortase (PDB ID Code: <b>2kid</b>) via docking was used as a screening tool for the studied compounds. The observed molecular compounds  ...[more]

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