Ontology highlight
ABSTRACT:
SUBMITTER: Enotarpi J
PROVIDER: S-EPMC7477203 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Enotarpi Jacopo J Tontini Marta M Balocchi Cristiana C van der Es Daan D Auberger Ludovic L Balducci Evita E Carboni Filippo F Proietti Daniela D Casini Daniele D Filippov Dmitri V DV Overkleeft Hermen S HS van der Marel Gijsbert A GA Colombo Cinzia C Romano Maria Rosaria MR Berti Francesco F Costantino Paolo P Codeé Jeroen D C JDC Lay Luigi L Adamo Roberto R
Nature communications 20200907 1
Neisseria meningitidis serogroup A capsular polysaccharide (MenA CPS) consists of (1 → 6)-2-acetamido-2-deoxy-α-D-mannopyranosyl phosphate repeating units, O-acetylated at position C3 or C4. Glycomimetics appear attractive to overcome the CPS intrinsic lability in physiological media, due to cleavage of the phosphodiester bridge, and to develop a stable vaccine with longer shelf life in liquid formulation. Here, we generate a series of non-acetylated carbaMenA oligomers which are proven more sta ...[more]