Ontology highlight
ABSTRACT:
SUBMITTER: Bhattacharya A
PROVIDER: S-EPMC7477576 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Bhattacharya Aditi A Janal Malvin N MN Veeramachaneni Ratna R Dolgalev Igor I Dubeykovskaya Zinaida Z Tu Nguyen Huu NH Kim Hyesung H Zhang Susanna S Wu Angie K AK Hagiwara Mari M Kerr A Ross AR DeLacure Mark D MD Schmidt Brian L BL Albertson Donna G DG
Scientific reports 20200907 1
Oral cancer patients experience pain at the site of the primary cancer. Patients with metastatic oral cancers report greater pain. Lack of pain identifies patients at low risk of metastasis with sensitivity = 0.94 and negative predictive value = 0.89. In the same cohort, sensitivity and negative predictive value of depth of invasion, currently the best predictor, were 0.95 and 0.92, respectively. Cancer pain is attributed to cancer-derived mediators that sensitize neurons and is associated with ...[more]