Ontology highlight
ABSTRACT:
SUBMITTER: Nichol RJO
PROVIDER: S-EPMC7478159 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Nichol Ryan J O RJO Khalaf Abedawn I AI Sooda Kartheek K Hussain Omar O Griffiths Hollie B S HBS Phillips Roger R Javid Farideh A FA Suckling Colin J CJ Allison Simon J SJ Scott Fraser J FJ
MedChemComm 20190718 9
Traditional cytotoxic agents which act through a DNA-alkylating mechanism are relatively non-specific, resulting in a small therapeutic window and thus limiting their effectiveness. In this study, we evaluate a panel of 24 non-alkylating Strathclyde Minor Groove Binders (S-MGBs), including 14 novel compounds, for <i>in vitro</i> anti-cancer activity against a human colon carcinoma cell line, a cisplatin-sensitive ovarian cancer cell line and a cisplatin-resistant ovarian cancer cell line. A huma ...[more]