Non-tuberculous mycobacterial infection and reactive dermatosis associated with adult-onset immunodeficiency due to anti-interferon-gamma autoantibodies: A case report.

ABSTRACT: INTRODUCTION:Anti-interferon-gamma (anti-IFN-?) autoantibody increases susceptibility to lower-virulence pathogens and causes immunodeficiency syndrome in HIV-negative patients. PATIENT CONCERNS:A 69-year-old Chinese man presented with a 2-month history of pruritic skin lesions on his forearms, trunk, and legs. He was diagnosed with 5 opportunistic infections without conventional immunosuppression-associated factors in past. The most conspicuous characteristics were recurrent pulmonary infection, persistent immunoglobulin E elevation and eosinophilia during the whole disease course. DIAGNOSIS:Enzyme-linked immunosorbent assay showed anti-IFN-? autoantibody positive. The final diagnosis for the patient was adult-onset immunodeficiency due to anti-IFN-? autoantibody, non-tuberculous mycobacterial (NTM) infection and reactive dermatosis. INTERVENTIONS:The patient underwent long-term anti-NTM and corticosteroid maintenance treatment. OUTCOMES:The patient was followed for 2 years during which opportunistic infection no longer happened, the immunoglobulin E level and eosinophil count reduced, the autoantibody levels remained largely steady and lung lesions absorbed. CONCLUSION:Clinicians should be vigilant for NTM infection in patients with anti-IFN-? autoantibodies, even when culture results are negative. Long-term anti-non-tuberculous mycobacteria and glucocorticoid regimens were effective.

SUBMITTER: Liang XN 

PROVIDER: S-EPMC7478425 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature