Ontology highlight
ABSTRACT:
SUBMITTER: Gomez Acuna LI
PROVIDER: S-EPMC7480116 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Gómez Acuña Luciana I LI Nazer Ezequiel E Rodríguez-Seguí Santiago A SA Pozzi Berta B Buggiano Valeria V Marasco Luciano E LE Agirre Eneritz E He Cody C Alló Mariano M Kornblihtt Alberto R AR
The Journal of cell biology 20200901 9
In mammals, argonaute (AGO) proteins have been characterized for their roles in small RNA-mediated posttranscriptional and also in transcriptional gene silencing. Here, we report a different role for AGO1 in estradiol-triggered transcriptional activation in human cells. We show that in MCF-7 mammary gland cells, AGO1 associates with transcriptional enhancers of estrogen receptor α (ERα) and that this association is up-regulated by treating the cells with estrogen (E2), displaying a positive corr ...[more]