Ontology highlight
ABSTRACT:
SUBMITTER: Ruffolo G
PROVIDER: S-EPMC7480916 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Annals of clinical and translational neurology 20200805 9
We compared GABAergic function and neuronal excitability in the hippocampal tissue of seven sporadic MTLE patients with a patient carrying a SCN1A loss-of-function mutation. All had excellent outcome from anterior temporal lobectomy, and neuropathological study always showed characteristic hippocampal sclerosis (Hs). Compared to MTLE patients, there was a more severe impairment of GABAergic transmission, due to the lower GABAergic activity related to the Na<sub>V</sub> 1.1 loss-of-function, in a ...[more]