Ontology highlight
ABSTRACT:
SUBMITTER: Hasenpusch-Theil K
PROVIDER: S-EPMC7481005 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Hasenpusch-Theil Kerstin K Laclef Christine C Colligan Matt M Fitzgerald Eamon E Howe Katherine K Carroll Emily E Abrams Shaun R SR Reiter Jeremy F JF Schneider-Maunoury Sylvie S Theil Thomas T
eLife 20200825
During the development of the cerebral cortex, neurons are generated directly from radial glial cells or indirectly via basal progenitors. The balance between these division modes determines the number and types of neurons formed in the cortex thereby affecting cortical functioning. Here, we investigate the role of primary cilia in controlling the decision between forming neurons directly or indirectly. We show that a mutation in the ciliary gene <i>Inpp5e</i> leads to a transient increase in di ...[more]