Ontology highlight
ABSTRACT:
SUBMITTER: Lopez-Lopez S
PROVIDER: S-EPMC7481794 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
López-López Susana S Monsalve Eva María EM Romero de Ávila María José MJ González-Gómez Julia J Hernández de León Natalia N Ruiz-Marcos Francisco F Baladrón Victoriano V Nueda María Luisa ML García-León María Jesús MJ Screpanti Isabella I Felli María Pía MP Laborda Jorge J García-Ramírez José Javier JJ Díaz-Guerra María José M MJM
Scientific reports 20200909 1
Macrophage activation by Toll receptors is an essential event in the development of the response against pathogens. NOTCH signaling pathway is involved in the control of macrophage activation and the inflammatory processes. In this work, we have characterized NOTCH signaling in macrophages activated by Toll-like receptor (TLR) triggering and determined that DLL1 and DLL4 are the main ligands responsible for NOTCH signaling. We have identified ADAM10 as the main protease implicated in NOTCH proce ...[more]