Creating Complex Polyacrylamide Hydrogel Structures Using 3D Printing with Applications to Mechanobiology.
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ABSTRACT: Due to its favorable physical and chemical properties, including chemical inertness, low fouling by biological molecules, high porosity and permeability, optical transparency, and adjustable elasticity, polyacrylamide has found a wide range of biomedical and non-biomedical applications. To further increase its versatility, this communication describes a simple method, using readily available reagents and equipment, for 3D printing polyacrylamide hydrogels at a resolution of 100-150 μm to create complex structures. As a demonstration of the application, the method is used for creating a lab-on-a-chip cell culture surface with micropatterned stiffness, which then leads to the discovery of stiffness-guided collective cell segregation distinct from durotaxis. The present technology is expected to unleash new applications such as the construction of biocompatible elastic medical devices and artificial organs.
SUBMITTER: Wang YL
PROVIDER: S-EPMC7482135 | biostudies-literature |
REPOSITORIES: biostudies-literature
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