Ontology highlight
ABSTRACT:
SUBMITTER: van de Weijer ML
PROVIDER: S-EPMC7482433 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
van de Weijer Michael L ML Krshnan Logesvaran L Liberatori Sabrina S Guerrero Elena Navarro EN Robson-Tull Jacob J Hahn Lilli L Lebbink Robert Jan RJ Wiertz Emmanuel J H J EJHJ Fischer Roman R Ebner Daniel D Carvalho Pedro P
Molecular cell 20200731 5
Misfolded proteins in the endoplasmic reticulum (ER) are degraded by ER-associated degradation (ERAD). Although ERAD components involved in degradation of luminal substrates are well characterized, much less is known about quality control of membrane proteins. Here, we analyzed the degradation pathways of two short-lived ER membrane model proteins in mammalian cells. Using a CRISPR-Cas9 genome-wide library screen, we identified an ERAD branch required for quality control of a subset of membrane ...[more]