Dataset Information

Association between muscle mass and insulin sensitivity independent of detrimental adipose depots in young adults with overweight/obesity.

ABSTRACT: BACKGROUND/OBJECTIVE:Less muscle mass has been associated with greater insulin resistance, but whether the association is independent of deleterious adipose depots in young adults with overweight/obesity who are at high risk for type 2 diabetes (T2DM) but are otherwise metabolically healthy is not known. The objective of this study was to determine whether muscle mass is independently associated with insulin sensitivity (IS) in young adults with overweight/obesity. SUBJECTS/METHODS:Cross-sectional Clinical Research Center study of 132 adults, 21-45yo, BMI???25?kg/m2 and metabolically healthy without T2DM. Primary independent variable: percent ideal appendicular lean mass (ALM) calculated as measured ALM divided by predicted ALM for age, weight, and height, calculated using validated NHANES data-based equation. Primary dependent variable: IS by Matsuda index. RESULTS:Mean age was 34.3?±?6.8 years, and mean BMI 35.8?±?5.8?kg/m2 (mean?±?SD). Individuals in the highest % ideal ALM tertile had mean IS 45% higher than the lowest tertile [6.94?±?0.85 vs 4.80?±?0.56 (mean?±?SEM), p?=?0.008] (sex interaction p?=?0.003). Men in the highest % ideal ALM tertile had mean IS twice the lowest tertile (5.47?±?0.68 vs 2.68?±?0.34, p?=?0.001), which remained significant controlling for visceral/subcutaneous and intermuscular adipose tissue, and intramyocellular and intrahepatic lipids (p?=?0.03). The association was not significant in women. CONCLUSIONS:Muscle mass is associated with IS independent of detrimental adipose depots in young men with overweight/obesity, at risk for T2DM but currently metabolically healthy. Muscle mass relative to sex, age, weight, and height-specific norms may be used to ascertain individual T2DM risk associated with low muscle mass.

SUBMITTER: Haines MS

PROVIDER: S-EPMC7483278 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Association between muscle mass and insulin sensitivity independent of detrimental adipose depots in young adults with overweight/obesity.

Haines Melanie S MS Dichtel Laura E LE Santoso Kate K Torriani Martin M Miller Karen K KK Bredella Miriam A MA

International journal of obesity (2005) 20200513 9

<h4>Background/objective</h4>Less muscle mass has been associated with greater insulin resistance, but whether the association is independent of deleterious adipose depots in young adults with overweight/obesity who are at high risk for type 2 diabetes (T2DM) but are otherwise metabolically healthy is not known. The objective of this study was to determine whether muscle mass is independently associated with insulin sensitivity (IS) in young adults with overweight/obesity.<h4>Subjects/methods</h ...[more]

PMID: 32404950

Similar Datasets

Project description:Background:Insulin resistance and accumulation of visceral adipose tissue (VAT) and intermuscular adipose tissue (IMAT) place aging adults with obesity at high risk of cardio-metabolic disease. A very low carbohydrate diet (VLCD) may be a means of promoting fat loss from the visceral cavity and skeletal muscle, without compromising lean mass, and improve insulin sensitivity in aging adults with obesity. Objective:To determine if a VLCD promotes a greater loss of fat (total, visceral and intermuscular), preserves lean mass, and improves insulin sensitivity compared to a standard CHO-based/low-fat diet (LFD) in older adults with obesity. Design:Thirty-four men and women aged 60-75?years with obesity (body mass index [BMI] 30-40?kg/m2) were randomized to a diet prescription of either a VLCD (<?10:25:>?65% energy from CHO:protein:fat) or LFD diet (55:25:20) for 8?weeks. Body composition by dual-energy X-ray absorptiometry (DXA), fat distribution by magnetic resonance imaging (MRI), insulin sensitivity by euglycemic hyperinsulinemic clamp, and lipids by a fasting blood draw were assessed at baseline and after the intervention. Results:Participants lost an average of 9.7 and 2.0% in total fat following the VLCD and LFD, respectively (p?<?0.01). The VLCD group experienced ~?3-fold greater loss in VAT compared to the LFD group (-?22.8% vs -?1.0%, p?<?0.001) and a greater decrease in thigh-IMAT (-?24.4% vs -?1.0%, p?<?0.01). The VLCD group also had significantly greater thigh skeletal muscle (SM) at 8?weeks following adjustment for change in total fat mass. Finally, the VLCD had greater increases in insulin sensitivity and HDL-C and decreases in fasting insulin and triglycerides compared to the LFD group. Conclusions:Weight loss resulting from consumption of a diet lower in CHO and higher in fat may be beneficial for older adults with obesity by depleting adipose tissue depots most strongly implicated in poor metabolic and functional outcomes and by improving insulin sensitivity and the lipid profile. Trial registration:NCT02760641. Registered 03 May 2016 - Retrospectively registered.

Dataset Information

Association between muscle mass and insulin sensitivity independent of detrimental adipose depots in young adults with overweight/obesity.

Publications

Association between muscle mass and insulin sensitivity independent of detrimental adipose depots in young adults with overweight/obesity.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets