Dataset Information

A preliminary examination of brain morphometry in youth with Down syndrome with and without parent-reported sleep difficulties.

ABSTRACT:

Background

Down syndrome is associated with poor sleep but little is known about its neural correlates.

Aims

The current research compared brain morphometry in youth with Down syndrome with parent-reported sleep problems (DS-S) to peers with Down syndrome (DS) and typical development (TD) without parent-reported sleep problems matched on age (M = 15.15) and sex ratio (62 % female).

Methods and procedures

Magnetic resonance imaging was completed on a 3 T scanner. Participants were stratified into groups based on parent-report: DS-S (n = 17), DS (n = 9), TD (n = 22). Brain morphometry, processed with the FreeSurfer Image Analysis Suite, was compared across groups. In addition, the co-occurrence of medical conditions in the DS groups was examined.

Outcomes and results

Youth with DS-S had reduced total, frontal, parietal, and temporal brain volumes relative to DS and TD peers. They also had higher rates of congenital heart defects than the DS-only group; however, this comorbidity did not appear to account for morphometry differences.

Conclusions and implications

Parent-reported sleep problems in DS appear to relate to global and localized volume reductions. These preliminary results have implications for understanding the neural correlates of poor sleep in DS; they also highlight the importance of examining relations between sleep and other medical comorbidities.

SUBMITTER: Lee NR

PROVIDER: S-EPMC7483358 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Publications

A preliminary examination of brain morphometry in youth with Down syndrome with and without parent-reported sleep difficulties.

Lee Nancy Raitano NR Perez Megan M Hamner Taralee T Adeyemi Elizabeth E Clasen Liv S LS

Research in developmental disabilities 20200224

<h4>Background</h4>Down syndrome is associated with poor sleep but little is known about its neural correlates.<h4>Aims</h4>The current research compared brain morphometry in youth with Down syndrome with parent-reported sleep problems (DS-S) to peers with Down syndrome (DS) and typical development (TD) without parent-reported sleep problems matched on age (M = 15.15) and sex ratio (62 % female).<h4>Methods and procedures</h4>Magnetic resonance imaging was completed on a 3 T scanner. Participant ...[more]

PMID: 32106035

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Dataset Information

A preliminary examination of brain morphometry in youth with Down syndrome with and without parent-reported sleep difficulties.

Background

Aims

Methods and procedures

Outcomes and results

Conclusions and implications

Publications

A preliminary examination of brain morphometry in youth with Down syndrome with and without parent-reported sleep difficulties.

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