Ontology highlight
ABSTRACT:
SUBMITTER: Liu J
PROVIDER: S-EPMC7483747 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Liu J J Chanumolu S K SK White K M KM Albahrani M M Otu H H HH Nawshad A A
Scientific reports 20200910 1
Cleft palate (CP) is one of the most common craniofacial birth defects, impacting about 1 in 800 births in the USA. Tgf-β3 plays a critical role in regulating murine palate development, and Tgf-β3 null mutants develop cleft palate with 100% penetrance. In this study, we compared global palatal transcriptomes of wild type (WT) and Tgf-β3 -/- homozygous (HM) mouse embryos at the crucial palatogenesis stages of E14.5, and E16.5, using RNA-seq data. We found 1,809 and 2,127 differentially expressed ...[more]