Mitochondrial Metabolism as a Target for Cancer Therapy.
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ABSTRACT:
SUBMITTER: Vasan K
PROVIDER: S-EPMC7483781 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Mitochondrial Metabolism as a Target for Cancer Therapy.
Vasan Karthik K Werner Marie M Chandel Navdeep S NS
Cell metabolism 20200714 3
Recent evidence in humans and mice supports the notion that mitochondrial metabolism is active and necessary for tumor growth. Mitochondrial metabolism supports tumor anabolism by providing key metabolites for macromolecule synthesis and generating oncometabolites to maintain the cancer phenotype. Moreover, there are multiple clinical trials testing the efficacy of inhibiting mitochondrial metabolism as a new cancer therapeutic treatment. In this review, we discuss the rationale of using these a ...[more]
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