Age, Sex, and Depot-Specific Differences in Adipose-Tissue Estrogen Receptors in Individuals with Obesity.
Ontology highlight
ABSTRACT: Objective
The aim of this study was to examine the effects of sex and menopausal status on depot-specific estrogen signaling in white adipose tissue (AT) in age-matched men and women with morbid obesity.Methods
A total of 28 premenopausal women, 16 postmenopausal women, and 27 age-matched men undergoing bariatric surgery were compared for omental (OM) AT (OMAT) and abdominal subcutaneous (SQ) AT (SQAT) genes and proteins.Results
With the exception of fasting nonesterified fatty acids being higher in women (P?ConclusionsIn morbid obesity, sex and age affect AT ERs, lipid metabolism, mitochondrial uncoupling protein 1, and inflammatory expression in an AT depot-dependent manner. The SQAT immunometabolic profile is heavily influenced by age and menopause status, more so than OMAT.
SUBMITTER: Porter JW
PROVIDER: S-EPMC7483923 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Age, Sex, and Depot-Specific Differences in Adipose-Tissue Estrogen Receptors in Individuals with Obesity.
Porter Jay W JW Barnas Jillian L JL Welly Rebecca R Spencer Nicole N Pitt James J Vieira-Potter Victoria J VJ Kanaley Jill A JA
Obesity (Silver Spring, Md.) 20200731 9
<h4>Objective</h4>The aim of this study was to examine the effects of sex and menopausal status on depot-specific estrogen signaling in white adipose tissue (AT) in age-matched men and women with morbid obesity.<h4>Methods</h4>A total of 28 premenopausal women, 16 postmenopausal women, and 27 age-matched men undergoing bariatric surgery were compared for omental (OM) AT (OMAT) and abdominal subcutaneous (SQ) AT (SQAT) genes and proteins.<h4>Results</h4>With the exception of fasting nonesterified ...[more]
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