Ontology highlight
ABSTRACT:
SUBMITTER: Potter ZE
PROVIDER: S-EPMC7484201 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Potter Zachary E ZE Lau Ho-Tak HT Chakraborty Sujata S Fang Linglan L Guttman Miklos M Ong Shao-En SE Fowler Douglas M DM Maly Dustin J DJ
Cell chemical biology 20200709 8
Solution-based structural techniques complement high-resolution structural data by providing insight into the oft-missed links between protein structure and dynamics. Here, we present Parallel Chemoselective Profiling, a solution-based structural method for characterizing protein structure and dynamics. Our method utilizes deep mutational scanning saturation mutagenesis data to install amino acid residues with specific chemistries at defined positions on the solvent-exposed surface of a protein. ...[more]