Ontology highlight
ABSTRACT:
SUBMITTER: Maciejowski J
PROVIDER: S-EPMC7484228 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Maciejowski John J Chatzipli Aikaterini A Dananberg Alexandra A Chu Kevan K Toufektchan Eleonore E Klimczak Leszek J LJ Gordenin Dmitry A DA Campbell Peter J PJ de Lange Titia T
Nature genetics 20200727 9
Chromothripsis and kataegis are frequently observed in cancer and may arise from telomere crisis, a period of genome instability during tumorigenesis when depletion of the telomere reserve generates unstable dicentric chromosomes<sup>1-5</sup>. Here we examine the mechanism underlying chromothripsis and kataegis by using an in vitro telomere crisis model. We show that the cytoplasmic exonuclease TREX1, which promotes the resolution of dicentric chromosomes<sup>4</sup>, plays a prominent role in ...[more]