Alternative end joining, clonal evolution, and escape from a telomere-driven crisis.
Ontology highlight
ABSTRACT: Telomere dysfunction and fusion play key roles in driving genomic instability and clonal evolution in many tumor types. We have recently described a role for DNA ligase III (LIG3) in facilitating the escape of cells from crisis induced by telomere dysfunction. Our data indicate that LIG3-mediated telomere fusion is important in facilitating clonal evolution.
SUBMITTER: Hendrickson EA
PROVIDER: S-EPMC4905247 | biostudies-other | 2015 Jan-Mar
REPOSITORIES: biostudies-other
ACCESS DATA