Dataset Information

Sensitization of the reinforcing value of food: a novel risk factor for overweight in adolescents.

ABSTRACT:

Background and objectives

The relative reinforcing value (RRV) of food is associated with increased energy intake and obesity and increases in RRV of food after repeated intake (sensitization) are related cross-sectionally and prospectively to higher BMI in adults. We examined the factors, such as delay discounting (DD), associated with sensitization of RRV to high energy density (HED) and low energy density (LED) food and how sensitization relates to zBMI in adolescents. We hypothesized that sensitization to HED food would be positively associated with zBMI, that sensitization to LED food would be negatively associated with zBMI, that DD would be associated with HED sensitization, and that LED sensitization and DD would moderate the relationships between HED sensitization and zBMI.

Subjects and methods

A population-based sample of 207 adolescents without obesity, aged 12-14 years was studied from June 2016-March 2019. The RRV of LED and HED foods were measured before and after two weeks of daily consumption along with zBMI and other potential factors related to eating and weight, including dietary restraint, hunger, food liking, and delay discounting (DD). Hierarchical regression models were used to determine the associations between these factors and sensitization and zBMI. We also examined LED sensitization and DD as potential moderators of the relationship between sensitization and zBMI.

Results

As hypothesized, dietary restraint and sensitization to HED food were associated with greater zBMI. Contrary to our original hypotheses, DD was not associated with sensitization, there was no relationship between sensitization to LED food and zBMI and neither LED sensitization or DD moderated the relationship between HED sensitization and zBMI.

Conclusions

Sensitization to repeated intake of HED food was associated with higher zBMI in adolescents without obesity. Sensitization may be a novel behavioral phenotype that may relate to overweight in youth.

SUBMITTER: Temple JL

PROVIDER: S-EPMC7484379 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Publications

Sensitization of the reinforcing value of food: a novel risk factor for overweight in adolescents.

Temple Jennifer L JL Ziegler Amanda M AM Crandall Amanda K AK Mansouri Tegan T Epstein Leonard H LH

International journal of obesity (2005) 20200714 9

<h4>Background and objectives</h4>The relative reinforcing value (RRV) of food is associated with increased energy intake and obesity and increases in RRV of food after repeated intake (sensitization) are related cross-sectionally and prospectively to higher BMI in adults. We examined the factors, such as delay discounting (DD), associated with sensitization of RRV to high energy density (HED) and low energy density (LED) food and how sensitization relates to zBMI in adolescents. We hypothesized ...[more]

PMID: 32665612

Similar Datasets

Project description:Background/objectivesCharacterizing behavioral phenotypes that predict increased zBMI gain during adolescence could identify novel intervention targets and prevent the development of obesity. The purpose of this study was to determine if sensitization of the relative reinforcing value (RRV) of high (HED) or low energy density (LED) foods predicts adolescent weight gain trajectories. A secondary aim was to test the hypothesis that relationships between sensitization of the RRV of food and weight change are moderated by delay discounting (DD).Subjects/methodsWe conducted a prospective, longitudinal cohort study in 201 boys and girls with an average zBMI of 0.4, who began the study between the ages of 12 and 14 years and completed the study 2 years later. Participants completed five laboratory visits where the RRV of HED and LED, and DD were assessed at a baseline (visits 1, 2, and 4) and then RRV was measured again after participants consumed a portion of the same HED and LED food for 2 weeks (visits 3 and 5; order counterbalanced). Increases (>1) in the RRV from baseline to post-daily intake were categorized as "sensitization" and decreases (≤1) were categorized as "satiation." Participants returned to the laboratory for follow-up visits at 6, 15, and 24 months to have height and weight taken and to complete additional assessments.ResultsSensitization to HED food was associated with a greater zBMI change over time (β = 0.0070; p = 0.035). There was no impact of sensitization to LED food or interaction between sensitization to HED and LED food on zBMI change and no moderation of DD on the relationship between HED sensitization and zBMI change (all p > 0.05).ConclusionOur prior work showed that sensitization to HED food is cross-sectionally associated with greater zBMI. This study extends this work by demonstrating that sensitization to HED food prospectively predicts increased zBMI gain over time in adolescents without obesity. Future studies should determine if sensitization can be modified or reduced through behavioral intervention.Trial registrationClinicaltrials.gov: NCT04027608.

Dataset Information

Sensitization of the reinforcing value of food: a novel risk factor for overweight in adolescents.

Background and objectives

Subjects and methods

Results

Conclusions

Publications

Sensitization of the reinforcing value of food: a novel risk factor for overweight in adolescents.

Similar Datasets

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