Ontology highlight
ABSTRACT:
SUBMITTER: Kawashima N
PROVIDER: S-EPMC7484840 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Kawashima Naomi N Ishikawa Yuichi Y Atsuta Yoshiko Y Sawa Masashi M Ozawa Yukiyasu Y Hayashi Masaki M Kohno Akio A Tomita Akihiro A Maeda Tomoya T Sakaida Emiko E Usuki Kensuke K Hagihara Maki M Kanamori Heiwa H Matsuoka Hiroshi H Kobayashi Miki M Asou Norio N Ohtake Shigeki S Matsumura Itaru I Miyazaki Yasushi Y Naoe Tomoki T Kiyoi Hitoshi H
Cancer science 20200529 7
In this phase II multicenter study (JALSG AML209-FLT3-SCT), we aimed to prospectively elucidate the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) at first complete remission (CR1) for FLT3-internal tandem duplication (ITD)-positive AML. Newly diagnosed de novo AML patients with FLT3-ITD were enrolled at the achievement of CR1 and received allo-HSCT as soon as possible after the first consolidation therapy. Mutations of 57 genes in AML cells at diagnosis were also analyze ...[more]