CD8⁺ tumor-infiltrating lymphocytes within the primary tumor of patients with synchronous de novo metastatic colorectal carcinoma do not track with survival.

ABSTRACT:

Objectives

Tumor-infiltrating lymphocytes (TIL), particularly CD8⁺ TILs in patients with colorectal cancer (CRC), are highly prognostic in the early-disease stages (I-II). In metastatic disease (stage IV; mCRC), their influence is less well defined. It has presumably failed to contain tumor cells to the primary site; however, is this evident? We explored the prognostic impact of TILs at the primary site in patients who presented de novo with mCRC.

Methods

Treatment-naïve patients (109) with mCRC were assessed for CD8⁺ TILs and PD-L1 expression. Microsatellite instability (MSI) was evaluated by IHC for PMS2 and MSH6 proteins and/or by PCR using the Bethesda panel.

Results

Microsatellite instability-high tumors had significantly more CD8

SUBMITTER: Millen R 

PROVIDER: S-EPMC7484874 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature