Prevalence, risk factors and associated ocular diseases of cerebral stroke: the population-based Beijing Eye Study.

ABSTRACT: OBJECTIVE:To assess the prevalence of cerebral stroke in the general population of Beijing and its association with systemic risk factors and ocular diseases. SETTING:The population-based Beijing Eye Study was conducted in a rural and urban region of Beijing. PARTICIPANTS:With eligibility criteria of age 50+ years?and living in the study regions, 3468 subjects (78.8%) out of 4403 eligible individuals participated. PRIMARY AND SECONDARY OUTCOME MEASURES:The study participants underwent a detailed systemic and ophthalmological examination and an interview in which the occurrence of a previous stroke was assessed. RESULTS:A previous stroke was reported by 235 individuals (7.33%; 95% CI 6.43% to 8.24%). The prevalence of previous stroke increased from 2.0% (95% CI 0.9% to 3.1%) in the age group of 50 to <55 years to 21.9% (95% CI 16.4% to 27.4%) in the age group of 80+ years. In multivariable regression analysis, a higher prevalence of previous stroke was correlated (Nagelkerke R2=0.20) with the systemic parameters of older age (p<0.001; OR 1.06; 95%?CI 1.04 to 1.08), male gender (p<0.001; OR 0.54; 95%?CI 0.40 to 0.74), lower quality of life score (p<0.001; OR 1.39; 95%?CI 1.25 to 1.55), higher prevalence of arterial hypertension (p<0.001; OR 2.86; 95%?CI 2.05 to 3.98), and cardiovascular disease (p<0.001; OR 1.8554; 95%?CI 1.34 to 2.56), and with the ocular parameter of higher prevalence of diabetic retinopathy (p<0.001; OR 4.41; 95%?CI 2.38 to 8.18) or alternatively, with higher stage of diabetic retinopathy (p<0.001; OR 1.64; 95%?CI 1.26 to 2.14). CONCLUSIONS:In this North Chinese population aged 50+ years, the prevalence of a previous stroke was 7.33% (95% CI 6.43% to 8.24%). After adjusting for systemic risk factors of older age, male gender and higher prevalence of arterial hypertension and cardiovascular disease, a higher prevalence of a previous stroke was significantly correlated with a higher prevalence and stage of diabetic retinopathy. The prevalence of a previous stroke increased for each step of an increase in the stage of diabetic retinopathy with an OR of 1.64 (95% CI 1.26 to 2.14), and it increased by the presence of diabetic retinopathy with an OR of 4.41 (95% CI 2.38 to 8.18).

SUBMITTER: Wang YX 

PROVIDER: S-EPMC7485244 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature