Ontology highlight
ABSTRACT:
SUBMITTER: Chen CC
PROVIDER: S-EPMC7485730 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Chen Chien-Cheng CC Wong Tzyy-Yue TY Chin Tzu-Yun TY Lee Wen-Hsien WH Kuo Chan-Yen CY Hsu Yi-Chiung YC
Aging 20200805 16
Although mechanical forces are involved in pressure-overloaded cardiomyopathy, their effects on gene transcription profiles are not fully understood. Here, we used next-generation sequencing (NGS) to investigate changes in genomic profiles after cyclic mechanical stretching of human cardiomyocytes. We found that 85, 87, 32, 29, and 28 genes were differentially expressed after 1, 4, 12, 24, and 48 hours of stretching. Furthermore, 10 of the 29 genes that were up-regulated and 11 of the 28 that we ...[more]