IL-21 mediates microRNA-423-5p /claudin-5 signal pathway and intestinal barrier function in inflammatory bowel disease.
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ABSTRACT:
SUBMITTER: Wang M
PROVIDER: S-EPMC7485739 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
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IL-21 mediates microRNA-423-5p /claudin-5 signal pathway and intestinal barrier function in inflammatory bowel disease.
Wang Mu M Guo Jian J Zhao Yi-Qing YQ Wang Jun-Ping JP
Aging 20200828 16
Inflammatory bowel disease (IBD) is a group of chronic and recurrent nonspecific inflammatory disorders, including Crohn's disease (CD) and ulcerative colitis (UC). Due to the persistent inflammation of intestinal mucosa caused by immune disorders, barrier dysfunction may be an essential cause of the pathogenesis of IBD. Therefore, exploring the mechanism is very important to clarify the pathogenesis of IBD. In our research, we provided evidence of IL-21 function in IBD. The junction complex pro ...[more]
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