Revisiting the association between human leukocyte antigen and end-stage renal disease.
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ABSTRACT:
SUBMITTER: Noureen N
PROVIDER: S-EPMC7485852 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Revisiting the association between human leukocyte antigen and end-stage renal disease.
Noureen Naila N Shah Farhad Ali FA Lisec Jan J Usman Hina H Khalid Mohammad M Munir Rimsha R Zaidi Nousheen N
PloS one 20200911 9
Multiple works have studied possible associations between human leukocyte antigen (HLA) alleles and end stage renal disease (ESRD) showing, however, contradictory and inconsistent results. Here, we revisit the association between ESRD and HLA antigens, comparing HLA polymorphism (at HLA-A, -B, -C, -DRB1, -DQB1 and DQA1 loci) in ESRD patients (n = 497) and controls (n = 672). Our data identified several HLA alleles that displayed a significant positive or negative association with ESRD. We also d ...[more]
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