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?-Catenin and Associated Proteins Regulate Lineage Differentiation in Ground State Mouse Embryonic Stem Cells.

ABSTRACT: Mouse embryonic stem cells (ESCs) cultured in defined medium resemble the pre-implantation epiblast in the ground state, with full developmental capacity including the germline. ?-Catenin is required to maintain ground state pluripotency in mouse ESCs, but its exact role is controversial. Here, we reveal a Tcf3-independent role of ?-catenin in restraining germline and somatic lineage differentiation genes. We show that ?-catenin binds target genes with E2F6 and forms a complex with E2F6 and HMGA2 or E2F6 and HP1?. Our data indicate that these complexes help ?-catenin restrain and fine-tune germ cell and neural developmental potential. Overall, our data reveal a previously unappreciated role of ?-catenin in preserving lineage differentiation integrity in ground state ESCs.

SUBMITTER: Tao F 

PROVIDER: S-EPMC7486223 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Mouse embryonic stem cells (ESCs) cultured in defined medium resemble the pre-implantation epiblast in the ground state, with full developmental capacity including the germline. β-Catenin is required to maintain ground state pluripotency in mouse ESCs, but its exact role is controversial. Here, we reveal a Tcf3-independent role of β-catenin in restraining germline and somatic lineage differentiation genes. We show that β-catenin binds target genes with E2F6 and forms a complex with E2F6 and HMGA  ...[more]

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