Ontology highlight
ABSTRACT:
SUBMITTER: Kim JK
PROVIDER: S-EPMC7486293 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Kim Jin Kyun JK Lee Cheol C Lim Seon Woo SW Adhikari Aniruddha A Andring Jacob T JT McKenna Robert R Ghim Cheol-Min CM Kim Chae Un CU
Nature communications 20200911 1
Why metalloenzymes often show dramatic changes in their catalytic activity when subjected to chemically similar but non-native metal substitutions is a long-standing puzzle. Here, we report on the catalytic roles of metal ions in a model metalloenzyme system, human carbonic anhydrase II (CA II). Through a comparative study on the intermediate states of the zinc-bound native CA II and non-native metal-substituted CA IIs, we demonstrate that the characteristic metal ion coordination geometries (te ...[more]