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Obesity is a potential risk factor contributing to clinical manifestations of COVID-19.

ABSTRACT: BACKGROUND:Since December 2019, novel coronavirus (SARS-CoV-2)-induced pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. COVID-19 patients demonstrated significantly different outcomes in clinic. We aimed to figure out whether obesity is a risk factor influencing the progression and prognosis of COVID-19. METHODS:95 patients with COVID-19 were divided into obesity group and non-obesity group according to their body mass index (BMI). The demographic data, clinical characteristics, laboratory examination, and chest computed tomography (CT) were collected, analyzed and compared between two groups. RESULTS:Our data showed that COVID-19 patients with obesity had more underlying diseases and higher mortality rate compared to those without obesity. Furthermore, patients with obesity also demonstrated more severe pathological change in lung and higher blood lymphocytes, triglycerides, IL-6, CRP, cystatin C, alanine aminotransferase (ALT), erythrocyte sedimentation rate (ESR), which may greatly influence disease progression and poor prognosis of COVID-19. CONCLUSIONS:It suggest that obesity contributes to clinical manifestations and may influence the progression and prognosis of COVID-19 and it is considered as a potential risk factor of the prognosis of COVID-19. Special medical care and appropriate intervention should be performed in obesity patients with COVID-19 during hospitalization and later clinical follow-up, especially for those with additional other comorbidities.

SUBMITTER: Kang Z

PROVIDER: S-EPMC7487073 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Obesity is a potential risk factor contributing to clinical manifestations of COVID-19.

Kang Zhenyu Z Luo Shanshan S Gui Yang Y Zhou Haifeng H Zhang Zili Z Tian Chunxia C Zhou Qiaoli Q Wang Quansheng Q Hu Yu Y Fan Heng H Hu Desheng D

International journal of obesity (2005) 20200913 12

<h4>Background</h4>Since December 2019, novel coronavirus (SARS-CoV-2)-induced pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. COVID-19 patients demonstrated significantly different outcomes in clinic. We aimed to figure out whether obesity is a risk factor influencing the progression and prognosis of COVID-19.<h4>Methods</h4>95 patients with COVID-19 were divided into obesity group and non-obesity group according to their body mass index (BMI). The demographic data, ...[more]

PMID: 32921796

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Project description:BACKGROUND/OBJECTIVES:During the 2019 coronavirus disease (COVID-19) outbreak, obesity may contribute to COVID-19 transmission and deterioration. In addition, many patients with COVID-19 infection have suffered liver damage which might contribute to a worse prognosis. We conducted a clinical epidemiological analysis to investigate the association of overweight/obesity and abnormal liver function (ALF) with hospitalized duration in patients infected with COVID-19. SUBJECTS/METHODS:Fifty-eight patients with diagnosed COVID-19 (22 women & 36 men; average age: 49.2?±?13.1?yr) were included, and their clinical data were collected at The Second Affiliated and Yuying Children's Hospital of Wenzhou Medical University, Zhejiang. Overweight/obesity was determined as body mass index (BMI) ?24?kg/m2, ALF was determined as alanine aminotransferase >40?U/L, and prolonged hospitalization was lasting more than the median value of the hospitalized days (19 days) in this population. RESULTS:The proportions of prolonged hospitalization were elevated in patients with overweight/obesity and ALF compared with those without overweight/obesity (62.1% versus 26.1%, P?=?0.010) and those without ALF (70.6% versus 41.5%, P?=?0.043). Kaplan-Meier analysis showed that the hospitalized duration was increased from the patients with neither overweight/obesity nor ALF to those with either overweight/obesity or ALF, and to those with both of overweight/obesity and ALF (mean with 95% confidence interval: 16.4 [14.5-18.3] versus 25.3 [21.6-29.1] versus 28.3 [24.6-32.0], P for trend?=?0.001). Being discharged from hospital in time was inversely and independently associated with BMI (hazard ratio [HR]?=?0.75, 95% CI: 0.63-0.90, P for trend?=?0.002) and ALT (HR?=?0.95, 95% CI: 0.92-0.99, P for trend?=?0.007). CONCLUSIONS:Present findings suggested that overweight/obesity and/or ALF contributed to predicting a probability of prolonged hospitalization in patients with COVID-19 infection, to whom extra attentions and precautions should be paid during clinical treatments.

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Obesity is a potential risk factor contributing to clinical manifestations of COVID-19.

Publications

Obesity is a potential risk factor contributing to clinical manifestations of COVID-19.

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