Ontology highlight
ABSTRACT:
SUBMITTER: Gao P
PROVIDER: S-EPMC7487091 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Gao Peng P Yang Wenxia W Sun Lin L
Oxidative medicine and cellular longevity 20200903
Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) serve as essential hubs for interorganelle communication in eukaryotic cells and play multifunctional roles in various biological pathways. A defect in ER-mitochondria signaling or MAMs dysfunction has pleiotropic effects on a variety of intracellular events, which results in disturbances of the mitochondrial quality control system, Ca<sup>2+</sup> dyshomeostasis, apoptosis, ER stress, and inflammasome activation, which all cont ...[more]