Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC7487169 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Li Yongjia Y Su Xinming X Rohatgi Nidhi N Zhang Yan Y Brestoff Jonathan R JR Shoghi Kooresh I KI Xu Yalin Y Semenkovich Clay F CF Harris Charles A CA Peterson Lindsay L LL Weilbaecher Katherine N KN Teitelbaum Steven L SL Zou Wei W
JCI insight 20200903 17
Obesity predisposes to cancer and a virtual universality of nonalcoholic fatty liver disease (NAFLD). However, the impact of hepatic steatosis on liver metastasis is enigmatic. We find that while control mice were relatively resistant to hepatic metastasis, those which were lipodystrophic or obese, with NAFLD, had a dramatic increase in breast cancer and melanoma liver metastases. NAFLD promotes liver metastasis by reciprocal activation initiated by tumor-induced triglyceride lipolysis in juxtap ...[more]