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Immunohistochemical basigin expression level in thyroid cancer tissues.


ABSTRACT: BACKGROUND:Thyroid cancer (TC) is the most common endocrine malignancy; basigin (also known as BSG) plays a crucial role in tumor cell invasion, metastasis, and angiogenesis. This study was designed to identify the change of BSG expression in TC and its possible potential mechanism. METHODS:The BSG expression levels in TC were demonstrated using data collected from in-house immunohistochemical (IHC), RNA-sequencing (RNA-seq), microarrays, and literatures. Integrated analysis was performed to determined BSG expression levels in TC comprehensively. The Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed with the integration of BSG co-expressed genes and differentially expressed genes (DEGs) in TC tissues to explore the potential mechanisms of BSG in TC. RESULTS:The protein expression level of BSG was significantly higher in TC cases based on the IHC experiments. In addition, the combined SMD for BSG expression was 0.39 (p < 0.0001), the diagnostic odds ratio was 3.69, and the AUC of the sROC curve was 0.6986 using 1182 TC cases and 437 non-cancerous cases from 17 independent datasets. Furthermore, BSG co-expressed genes tended to be enriched in gene terms of the extracellular matrix (ECM), cell adhesion, and cell-cell interactions. The expression levels of nine hub BSG co-expressed genes were markedly upregulated in TC cases. CONCLUSION:BSG expression levels were closely correlated with the progression of TC and may affect the signals of the ECM, cell adhesion, and cell-cell interactions.

SUBMITTER: Guo WP 

PROVIDER: S-EPMC7487720 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Immunohistochemical basigin expression level in thyroid cancer tissues.

Guo Wan-Ping WP   Tang Deng D   Pang Yu-Yan YY   Li Xiao-Jiao XJ   Chen Gang G   Huang Zhi-Guang ZG   Tang Xiao-Zhun XZ   Lai Qin-Qiao QQ   Gan Jin-Yan JY   Huang Xiao-Li XL   Liu Xiao-Fan XF   Wei Zhi-Xiao ZX   Ma Wei W  

World journal of surgical oncology 20200905 1


<h4>Background</h4>Thyroid cancer (TC) is the most common endocrine malignancy; basigin (also known as BSG) plays a crucial role in tumor cell invasion, metastasis, and angiogenesis. This study was designed to identify the change of BSG expression in TC and its possible potential mechanism.<h4>Methods</h4>The BSG expression levels in TC were demonstrated using data collected from in-house immunohistochemical (IHC), RNA-sequencing (RNA-seq), microarrays, and literatures. Integrated analysis was p  ...[more]

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