Ontology highlight
ABSTRACT:
SUBMITTER: Bianchi M
PROVIDER: S-EPMC6104742 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Bianchi Matteo M Turner Hannah L HL Nogal Bartek B Cottrell Christopher A CA Oyen David D Pauthner Matthias M Bastidas Raiza R Nedellec Rebecca R McCoy Laura E LE Wilson Ian A IA Burton Dennis R DR Ward Andrew B AB Hangartner Lars L
Immunity 20180807 2
Characterizing polyclonal antibody responses via currently available methods is inherently complex and difficult. Mapping epitopes in an immune response is typically incomplete, which creates a barrier to fully understanding the humoral response to antigens and hinders rational vaccine design efforts. Here, we describe a method of characterizing polyclonal responses by using electron microscopy, and we applied this method to the immunization of rabbits with an HIV-1 envelope glycoprotein vaccine ...[more]