Ontology highlight
ABSTRACT:
SUBMITTER: Singh D
PROVIDER: S-EPMC7487995 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Singh Dave D Balaguer Victor V Astbury Carol C Wählby-Hamrén Ulrika U Jimenez Eulalia E Seoane Beatriz B Villarroel Cristina C Lei Alejhandra A Aggarwal Ajay A Psallidas Ioannis I
Respiratory research 20200909 Suppl 1
<h4>Background</h4>Navafenterol (AZD8871) is a dual-pharmacology muscarinic antagonist β<sub>2-</sub>agonist (MABA) molecule in development for the treatment of chronic obstructive pulmonary disease (COPD). The pharmacodynamics, safety and tolerability of single doses of navafenterol were investigated in patients with moderate to severe COPD.<h4>Methods</h4>This was a randomized, five-way complete cross-over study. Patients received single doses of navafenterol 400 μg, navafenterol 1800 μg and p ...[more]