Remodeling the Bone Marrow Microenvironment - A Proposal for Targeting Pro-inflammatory Contributors in MPN.
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ABSTRACT:
SUBMITTER: Jutzi JS
PROVIDER: S-EPMC7489333 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Remodeling the Bone Marrow Microenvironment - A Proposal for Targeting Pro-inflammatory Contributors in MPN.
Jutzi Jonas Samuel JS Mullally Ann A
Frontiers in immunology 20200831
Philadelphia-negative myeloproliferative neoplasms (MPN) are malignant bone marrow (BM) disorders, typically arising from a single somatically mutated hematopoietic stem cell. The most commonly mutated genes, <i>JAK2</i>, <i>CALR</i>, and <i>MPL</i> lead to constitutively active JAK-STAT signaling. Common clinical features include myeloproliferation, splenomegaly and constitutional symptoms. This review covers the contributions of cellular components of MPN pathology (e.g., monocytes, megakaryoc ...[more]
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