Ontology highlight
ABSTRACT:
SUBMITTER: Zatulovskiy E
PROVIDER: S-EPMC7489475 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Zatulovskiy Evgeny E Zhang Shuyuan S Berenson Daniel F DF Topacio Benjamin R BR Skotheim Jan M JM
Science (New York, N.Y.) 20200701 6502
Cell size is fundamental to cell physiology. For example, cell size determines the spatial scale of organelles and intracellular transport and thereby affects biosynthesis. Although some genes that affect mammalian cell size have been identified, the molecular mechanisms through which cell growth drives cell division have remained elusive. We show that cell growth during the G<sub>1</sub> phase of the cell division cycle dilutes the cell cycle inhibitor Retinoblastoma protein (Rb) to trigger div ...[more]