Ontology highlight
ABSTRACT:
SUBMITTER: Rojas-Prats E
PROVIDER: S-EPMC7912371 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Rojas-Prats Elisa E Tosat-Bitrián Carlota C Martínez-González Loreto L Nozal Vanesa V Pérez Daniel I DI Martínez Ana A Martínez Ana A
Pharmaceutics 20210128 2
A potent cell division cycle 7 (CDC7) kinase inhibitor, known as PHA-767491, has been described to reduce the transactive response DNA binding protein of 43 KDa (TDP-43) phosphorylation in vitro and in vivo, which is one of the main proteins found to aggregate and accumulate in the cytoplasm of motoneurons in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) patients. However, the main drawback of this compound is its low permeability to the central nervous system (CNS), limi ...[more]