Ontology highlight
ABSTRACT:
SUBMITTER: Saxena M
PROVIDER: S-EPMC7490970 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Saxena Mayur M Changede Rishita R Hone James J Wolfenson Haguy H Sheetz Michael P MP
Nano letters 20171127 12
Cell growth depends upon formation of cell-matrix adhesions, but mechanisms detailing the transmission of signals from adhesions to control proliferation are still lacking. Here, we find that the scaffold protein talin undergoes force-induced cleavage in early adhesions to produce the talin rod fragment that is needed for cell cycle progression. Expression of noncleavable talin blocks cell growth, adhesion maturation, proper mechanosensing, and the related property of EGF activation of motility. ...[more]