Ontology highlight
ABSTRACT:
SUBMITTER: Wang W
PROVIDER: S-EPMC7491489 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Wang Wei W Niu Xiang X Stuart Tim T Jullian Estelle E Mauck William M WM Kelly Robert G RG Satija Rahul R Christiaen Lionel L
Nature cell biology 20190603 6
In vertebrates, multipotent progenitors located in the pharyngeal mesoderm form cardiomyocytes and branchiomeric head muscles, but the dynamic gene expression programmes and mechanisms underlying cardiopharyngeal multipotency and heart versus head muscle fate choices remain elusive. Here, we used single-cell genomics in the simple chordate model Ciona to reconstruct developmental trajectories forming first and second heart lineages and pharyngeal muscle precursors and characterize the molecular ...[more]