Mutational resilience of antiviral restriction favors primate TRIM5? in host-virus evolutionary arms races.
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ABSTRACT:
SUBMITTER: Tenthorey JL
PROVIDER: S-EPMC7492085 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races.
Tenthorey Jeannette L JL Young Candice C Sodeinde Afeez A Emerman Michael M Malik Harmit S HS
eLife 20200915
Host antiviral proteins engage in evolutionary arms races with viruses, in which both sides rapidly evolve at interaction interfaces to gain or evade immune defense. For example, primate TRIM5α uses its rapidly evolving 'v1' loop to bind retroviral capsids, and single mutations in this loop can dramatically improve retroviral restriction. However, it is unknown whether such gains of viral restriction are rare, or if they incur loss of pre-existing function against other viruses. Using deep mutat ...[more]
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